25 Oct 2019 By our definition, then, pleiotropy means that one variant shows significant associations across GWASs of multiple traits. We additionally restrict

If the goal is to estimate the pleiotropy of null mutations to answer questions about evolution, then those mutations too pleiotropic to ever contribute to evolution are

Any phenotype that is a secondary manifestation of a mutant gene. ~ is the condition in which a single mutant gene affects two or more distinct and seemingly unrelated traits. See also: What is the meaning of Genes, More, Trans, Organism, Gene? Pleated sheet : Meaning of pleiotropy. Pleiotropic gene action can limit the rate of multivariate evolution when natural selection, sexual selection or artificial selection on one trait favours one specific version of the gene, while selection on other traits favors a different allele. Pleiotropic cytokine: cytokine that affects the activity of multiple cell types.

Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Pleiotropy can arise from several distinct but potentially overlapping mechanisms, such as gene Definition of pleiotropy. genetics. : the phenomenon of a single gene influencing two or more distinct phenotypic traits : the quality or state of being pleiotropic In genetics, there's a concept called pleiotropy, which posits that a single gene can influence multiple traits. [Steven] Tanksley suggests there's substantial evidence that at least 2019-07-11 · Pleiotropy is the expression of multiple traits by a single gene.

pleiotropic in Chinese : :多种的…. click for more detailed Chinese translation, meaning, pronunciation and example sentences.

Dessa uttryckta Home based leisure meaning in spanish. of genes in common diseases, and that many of those genes are pleiotropic, that is, shared by several diseases. Pleiotropic definition is - producing more than one effect; especially : having multiple phenotypic expressions.

[ pli-ot´rŏ-pe] the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen.

Word. Genetic Pleiotropy.

Genetics.
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Pleiotropy (from Greek πλείων pleion, "more", and τρόπος tropos, "way") occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene.

Info. WordSense - English dictionary containing information about the meaning, the spelling, translations and more.We answer the questions: What does pleiotropic‎ mean?
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Définition. pléiotropie , nom féminin. Sens 1. Biologie · Qualité d'un gène ou d' une protéine ayant la capacité de gouverner plusieurs caractères et de déterminer

A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene Conclusions We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood mean corpuscular volume and mean corpuscular hemoglobin (p < 8 × 10−9). Genome-wide association meta-analysis identifies pleiotropic risk loci for Additionally, three previously unknown loci reached suggestive significance Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from ELAVL4; and rs6990042, SGCZ) achieved a nominal statistical significance. The aim of this article is to survey the pleiotropic e ects of niacin on Concomitantly, it led to a mild increase in MPV (mean platelet. volume) Many translated example sentences containing "pleiotropic effects" within the meaning of Article 2(a) of the latter directive and contains measures compliance CONCLUSIONS We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us tract infections and pleiotropic effects on the cardiovascular system.